一、个人信息：曾江正，教授/主任医师，肿瘤学博士，硕士生/博士生导师
二、教育经历：
2015/09-2018/06，南方医科大学，肿瘤学，博士，导师：罗荣城
2000/09-2004/07，中南大学湘雅医学院，中西医结合临床，硕士，导师：董克礼
1995/09-2000/07，湖南中医学院，中西医结合临床，本科
三、主要工作经历：
2004/07-2007/12，海南医学院附属医院，肿瘤内科，住院医师，助教；
2008/01-2012/12，海南医学院附属医院，肿瘤内科，主治医师，讲师；
2013/01-2017/12，海南医学院附属医院，肿瘤内科，副主任医师，副教授；
2018/01-现在，海南医学院第一附属医院，肿瘤内科，主任医师；
2018/01-现在，海南医学院第一附属医院，肿瘤内科，教授。
四、学术成果：
课题：
2012.01-2013.12 冷循环射频消融治疗后肝癌患者调节性T细胞频率变化及其对预后的影响 海南省自然科学基金811211
2016.01-2018.12 LncRNA靶向EMT相关信号通路调控肝癌RFA术后残余灶侵袭转移 海南省自然科学基金面上项目20168307
2020.01-2023.12 LncRNA FUNDC2P4通过转录因子CBX7调控CDH1在肝癌射频消融后残癌细胞EMT的机制研究 国家自然科学基金81960549
2021.12-2023.12 肝癌细胞来源外泌体circ_0003759介导巨噬细胞M2极化促进肝癌侵袭转移的机制研究（海南省科技厅，高层次人才研究课题，820RC761）
2022.01-2025.12 缺氧诱导LncRNA CTD-2510F5.4通过抑制HUWE1泛素化修饰MYC形成正反馈回路促进肝癌进展的机制研究 国家自然科学基金82160556
2022.01-2023.12 缺氧相关LncRNA CTD-2510F5.4泛素化降解MYC形成正反馈回路促进肝癌进展的研究 海南省重点研发项目ZDYF2021SHFZ251
论文：
1. Wang-Yuan Z, Jiang-Zheng Z, Lu YD, Hao XB, Hong T, Huang F, Lei JH, He ZH,HuangMZ.Clinical efficacy of metronomic chemotherapy after cool-tip radiofrequency ablation in thetreatment of hepatocellular carcinoma. Int J Hyperthermia. 2016 Mar;32(2):193-8.
2. Zeng J, Yang L, Huang F, Hong T, He Z, Lei J, Sun H, Lu Y, Hao X. The metronomic therapy with prednisone, etoposide, and cyclophosphamide reduces the serum levels of VEGF and circulating endothelial cells and improves response rates and progression-free survival in patients with relapsed or refractory non-Hodgkin's lymphoma. Cancer Chemother Pharmacol. 2016 Oct;78(4):801-8.
3. 曾江正，雷俊华，黄芬，何志惠. 席明纳教学方法在内科学见习教学中的应用研究[J]. 中华医学教育杂志，2017，37（3）：414-418.
4. 曾江正，蔡兴锐，黄芬，雷俊华，何志惠，孙华茂，卢彦达. 体外不完全射频消融后肝癌细胞上皮-间质转化相关长链非编码 RNA 差异表达，介入放射学杂志，2017，26（9）：835-841.
5. Jiang-ZhengZeng, YuLiu, FenHuang, Zhi-HuiHe, HuamaoSun, Yan-DaLu, Jun-HuaLei, Rong-ChengLuo. Glypican-3-specific cytotoxic T lymphocytes induced by human leucocyte antigen-A*0201-restricted peptide effectively kill hepatocellular carcinoma cells in vitro. Asian Pacific Journal of Tropical Medicine, November 2017; 10(11): 1084-1089.
6. Jiangzheng Zeng, Xinrui Cai, Xinbao Hao, Fen Huang, Zhihui He, Huamao Sun, Yanda Lu, Junhua Lei, Wangyuan Zeng, Yu Liu, Rongcheng Luo. LncRNA FUNDC2P4 down-regulation promotes epithelial-mesenchymal transition by reducing E-cadherin expression in residual hepatocellular carcinoma after insufficient radiofrequency ablation. International Journal of Hyperthermia. 2018 Sep;34(6):802-811.
7. Yang C, Cai X, Yu M, Wang B, Wang S, He Z, Zeng J, Zhang B, Lu Y. Long noncoding RNA OR3A4 promotes the proliferation and invasion of osteosarcoma cells by sponging miR-1227-5p. J Bone Oncol. 2020 Feb 1;21:100278. doi: 10.1016/j.jbo.2020.100278. PMID: 32082982; PMCID: PMC7025082.
8. 张海航,曾江正,朱旭,孙华茂,杨璐,付裕,卢彦达.基于表观遗传因子的肝细胞癌预后模型的构建和验证[J/OL].海南医学院学报:1-20[2022-03-29
9. Peng Z, Liu T, Wei J, Wang A, He Y, Yang L, Zhang X, Fan N, Luo S, Li Z, Gu K, Lu J, Xu J, Fan Q, Xu R, Zhang L, Li E, Sun Y, Yu G, Bai C, Liu Y, Zeng J, Ying J, Liang X, Xu N, Gao C, Shu Y, Ma D, Dai G, Li S, Deng T, Cui Y, Fang J, Ba Y, Shen L. Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing, locally advanced or metastatic gastric or gastroesophageal junction cancer: a single-arm phase II study. Cancer Commun (Lond). 2021 Nov;41(11):1173-1182. doi: 10.1002/cac2.12214.
10. Xu Danni, Zeng Jiangzheng, Sun Huamao, Pan Yinglian, Yang Changcheng & Lu Yanda. Chaperonin containing TCP1 subunit 3 (CCT3) promotes cisplatin resistance of lung adenocarcinoma cells through targeting the Janus kinase 2/signal transducers and activators of transcription 3 (JAK2/STAT3) pathway. Bioengineered. 2021 Dec;12(1):7335-7347
11. Lu Y, Lu C, Xu D, Huang F, He Z, Lei J, Sun H, Zeng J. Computed Tomography-Guided Percutaneous Radiofrequency Ablation in Older Adults With Early-Stage Peripheral Lung Cancer: A Retrospective Cohort Study. Cancer Control. 2022 Jan-Dec;29:10732748211070702.
12. Tanjie Chang, Liangxia Yang, Xiaojing Wang, Yanda Lu, Lu Yang, Changcheng Yang, Xingrui Cai, Jingquan Li, Jiangzheng Zeng. A CD8+ T cell-related genes prognostic model for hepatocellular carcinoma patients. Scand J Immunol. 2022;96(6):e13216.
13. Xiaojing Wang, Wangyuan Zeng, Lu Yang, Tanjie Chang, Jiangzheng Zeng. Epithelial-mesenchymal transition-related gene prognostic index and phenotyping clusters for hepatocellular carcinoma patients. Cancer Genetics. 2023;274:41-50.
14. Zulipiya Abulihaiti, Weihong Li, Liangyu Yang, Haihang Zhang, Ainong Du, Ni Tang, Yanda Lu & Jiangzheng Zeng. Hypoxia-driven lncRNA CTD-2510F5.4: a potential player in hepatocellular carcinoma’s prognostic stratification, cellular behavior, tumor microenvironment, and therapeutic response. Mol Biol Rep 51, 905 (2024).
五、学术组织兼职：
中国抗癌协会肿瘤疫苗专业委员会委员
中国抗癌协会多原发和不明原发肿瘤专业委员会委员
中国抗癌协会肿瘤神经病学专业委员会委员
海南医学会内科专业委员会副主任委员
海南省抗癌协会肿瘤分子靶向与免疫专业委员会副主任委员
海南省中医药学会肿瘤专业委员会副主任委员
海南省肿瘤生物免疫协会常委
六、获得奖励：
海南省“515人才工程”第三层次人选
海南省自由贸易港D类人才
七、联系方式： zengjiangzh@muhn.edu.cn
